' 
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
9.5
Calcium fosfomycin effective for UTIs
Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?
High relevance to treatment efficacy
We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
Read More
8
Zinc-Infused Catheters Reduce Infections
Antimicrobial and Antibiofilm Activities of Urinary Catheter Incorporated with ZnO-Carbon Nanotube.
High relevance to zinc's effectiveness
We investigated the potential of a new type of urinary catheter to tackle catheter-associated urinary tract infections (CAUTIs). By incorporating zinc oxide-carbon nanotubes (ZnO-CNT) into a silicone catheter, we explored how this innovative design could inhibit infection-causing bacteria effectively.
Utilizing a combination of laboratory techniques like scanning electron microscopy and dynamic light scattering, we analyzed the structure of our ZnO-CNT catheter, which showed promising antibacterial properties. Notably, we found that the ZnO-CNT infusion significantly reduced biofilm formation—one of the main challenges in urinary catheters—demonstrating up to 56% inhibition in bacterial growth compared to standard silicone catheters.
The study revealed that ZnO-CNT not only holds antimicrobial potential but may also provide a more comfortable alternative to existing metal-coated options, like those using silver or gold. With our findings, we hope to present a viable strategy for reducing the discomfort and risks associated with traditional catheters while addressing a prevalent healthcare concern.
Utilizing a combination of laboratory techniques like scanning electron microscopy and dynamic light scattering, we analyzed the structure of our ZnO-CNT catheter, which showed promising antibacterial properties. Notably, we found that the ZnO-CNT infusion significantly reduced biofilm formation—one of the main challenges in urinary catheters—demonstrating up to 56% inhibition in bacterial growth compared to standard silicone catheters.
The study revealed that ZnO-CNT not only holds antimicrobial potential but may also provide a more comfortable alternative to existing metal-coated options, like those using silver or gold. With our findings, we hope to present a viable strategy for reducing the discomfort and risks associated with traditional catheters while addressing a prevalent healthcare concern.
Read More
9
Zinc nanoparticle effectiveness confirmed
Antimicrobial efficacy of Mentha piperata-derived biogenic zinc oxide nanoparticles against UTI-resistant pathogens.
Promising against UTI pathogens
We investigated the potential of zinc oxide nanoparticles (ZnO NPs) derived from Mentha piperata, aiming to tackle urinary tract infections (UTIs) caused by antibiotic-resistant pathogens. Our study utilized an agar well diffusion assay to assess the effectiveness of these biogenic nanoparticles against notable bacteria, including Proteus mirabilis and Pseudomonas aeruginosa, as well as the fungal strain Candida albicans.
The results were promising; we found that the ZnO NPs showed significantly higher inhibition of these pathogens compared to conventional synthetic antibiotics. Interestingly, the zinc nanoparticles alone outperformed combinations with plant extracts. The analysis tools we used, including UV-Vis spectroscopy and scanning electron microscopy (SEM), indicated that the nanoparticles have a well-defined structure and favorable properties for attacking the bacteria.
As we dived deeper into the mechanisms, it appeared that higher concentrations of ZnO NPs triggered oxidative stress in the pathogen's cells. This interaction may damage the cell membrane, resulting in cell death and confirming their excellent dose-dependent antimicrobial effects against UTI-causing microorganisms. These findings highlight the potential of utilizing natural sources for developing new antimicrobial solutions to combat resistant infections.
The results were promising; we found that the ZnO NPs showed significantly higher inhibition of these pathogens compared to conventional synthetic antibiotics. Interestingly, the zinc nanoparticles alone outperformed combinations with plant extracts. The analysis tools we used, including UV-Vis spectroscopy and scanning electron microscopy (SEM), indicated that the nanoparticles have a well-defined structure and favorable properties for attacking the bacteria.
As we dived deeper into the mechanisms, it appeared that higher concentrations of ZnO NPs triggered oxidative stress in the pathogen's cells. This interaction may damage the cell membrane, resulting in cell death and confirming their excellent dose-dependent antimicrobial effects against UTI-causing microorganisms. These findings highlight the potential of utilizing natural sources for developing new antimicrobial solutions to combat resistant infections.
Read More
Most Useful Reviews
8.3
Twitching alleviated
After experiencing my eye twitching and a racing heart, likely from Covid and stress at age 30, I decided to try magnesium for the first time. I wanted pure glycinate, but it wasn’t available, so I opted for this product due to its reasonable price. It contains various forms of magnesium, with glycinate in second place. I noticed the eye twitching stopped almost immediately. While taking other vitamins, I had to adjust my vitamin D dose, which I took separately and reduced from three to two tablets. The size of the tablets is on the larger side for me, but they have significantly improved my condition, and I’ve had no gastrointestinal problems with this brand.
Read More
3.5
Upset experienced
I have been taking this for a week and experienced an upset in my gastrointestinal tract from the first day. While it hasn't been critical, it is certainly not pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
- All Researches
9.5
Calcium fosfomycin effective for UTIs
Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?
High relevance to treatment efficacy
We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
Read More
9.5
Zinc enhances catheter antimicrobial effects
Dual-Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity.
Evaluates combined zinc and silver
We focused on a new approach to tackle urinary tract infections (UTIs), a common issue many people face, particularly from catheters. This study introduced a dual-layer catheter design that combines zinc and silver nanoparticles to enhance antibacterial properties while minimizing potential harm to human cells. The zinc layer works alongside silver to not only provide an immediate defense against bacteria but also ensures a controlled release of silver over time.
Our findings showed that the zinc and silver combination effectively fought off UTI pathogens, with reductions of up to 99.9% for E. coli and 99.7% for S. aureus. This dual-layer approach significantly outperformed both regular silver-coated and uncoated catheters, particularly in limiting biofilm formation and inflammation in a rabbit model. So, while zinc alone isn't the primary focus here, its presence alongside silver appears crucial in enhancing the overall effectiveness of the catheter technology.
Although further studies are needed, this innovative strategy shows promise for improving long-term solutions in preventing catheter-associated urinary tract infections.
Our findings showed that the zinc and silver combination effectively fought off UTI pathogens, with reductions of up to 99.9% for E. coli and 99.7% for S. aureus. This dual-layer approach significantly outperformed both regular silver-coated and uncoated catheters, particularly in limiting biofilm formation and inflammation in a rabbit model. So, while zinc alone isn't the primary focus here, its presence alongside silver appears crucial in enhancing the overall effectiveness of the catheter technology.
Although further studies are needed, this innovative strategy shows promise for improving long-term solutions in preventing catheter-associated urinary tract infections.
Read More
9
Calcium's role in UTI prevention
Non Clinical Model to Assess the Mechanism of Action of a Combined Hyaluronic Acid, Chondroitin Sulfate and Calcium Chloride: HA+CS+CaCl Solution on a 3D Human Reconstructed Bladder Epithelium.
Relevant to urinary infection treatments
We investigated how a combination of hyaluronic acid, chondroitin sulfate, and calcium chloride (collectively referred to as HA+CS+CaCl) could help in preventing urinary tract infections (UTIs). This study used a three-dimensional model of human bladder tissue to assess this solution’s effectiveness. Our focus was on how well it could inhibit bacterial growth, form protective films on bladder surfaces, and prevent bacterial adhesion and biofilm formation.
Our results indicated that HA+CS+CaCl showed promising properties in counteracting bacterial invasion. Specifically, the calcium in this combination played a role in this physico-mechanical mode of action. While we understand that isolating the effects of calcium alone is challenging, the overall findings suggest that this medical solution could offer a viable alternative to antibiotics for treating recurrent UTIs.
By reducing bacterial adherence to the bladder epithelium, HA+CS+CaCl might help in better managing and reducing infections. This approach can be particularly appealing, considering the rising concern over antibiotic resistance in treating UTIs.
Our results indicated that HA+CS+CaCl showed promising properties in counteracting bacterial invasion. Specifically, the calcium in this combination played a role in this physico-mechanical mode of action. While we understand that isolating the effects of calcium alone is challenging, the overall findings suggest that this medical solution could offer a viable alternative to antibiotics for treating recurrent UTIs.
By reducing bacterial adherence to the bladder epithelium, HA+CS+CaCl might help in better managing and reducing infections. This approach can be particularly appealing, considering the rising concern over antibiotic resistance in treating UTIs.
Read More
9
Zinc nanoparticle effectiveness confirmed
Antimicrobial efficacy of Mentha piperata-derived biogenic zinc oxide nanoparticles against UTI-resistant pathogens.
Promising against UTI pathogens
We investigated the potential of zinc oxide nanoparticles (ZnO NPs) derived from Mentha piperata, aiming to tackle urinary tract infections (UTIs) caused by antibiotic-resistant pathogens. Our study utilized an agar well diffusion assay to assess the effectiveness of these biogenic nanoparticles against notable bacteria, including Proteus mirabilis and Pseudomonas aeruginosa, as well as the fungal strain Candida albicans.
The results were promising; we found that the ZnO NPs showed significantly higher inhibition of these pathogens compared to conventional synthetic antibiotics. Interestingly, the zinc nanoparticles alone outperformed combinations with plant extracts. The analysis tools we used, including UV-Vis spectroscopy and scanning electron microscopy (SEM), indicated that the nanoparticles have a well-defined structure and favorable properties for attacking the bacteria.
As we dived deeper into the mechanisms, it appeared that higher concentrations of ZnO NPs triggered oxidative stress in the pathogen's cells. This interaction may damage the cell membrane, resulting in cell death and confirming their excellent dose-dependent antimicrobial effects against UTI-causing microorganisms. These findings highlight the potential of utilizing natural sources for developing new antimicrobial solutions to combat resistant infections.
The results were promising; we found that the ZnO NPs showed significantly higher inhibition of these pathogens compared to conventional synthetic antibiotics. Interestingly, the zinc nanoparticles alone outperformed combinations with plant extracts. The analysis tools we used, including UV-Vis spectroscopy and scanning electron microscopy (SEM), indicated that the nanoparticles have a well-defined structure and favorable properties for attacking the bacteria.
As we dived deeper into the mechanisms, it appeared that higher concentrations of ZnO NPs triggered oxidative stress in the pathogen's cells. This interaction may damage the cell membrane, resulting in cell death and confirming their excellent dose-dependent antimicrobial effects against UTI-causing microorganisms. These findings highlight the potential of utilizing natural sources for developing new antimicrobial solutions to combat resistant infections.
Read More
9
Zinc-nanoparticle synergy combats UTIs
Synergistic Antibacterial Potential of 6-Pentyl-α-pyrone Lactone and Zinc Oxide Nanoparticles against Multidrug-Resistant Isolated from Urinary Tract Infections in Humans.
Relevant use of zinc in UTIs
We explored the antibacterial properties of zinc oxide nanoparticles (ZnONPs) and a natural compound called 6-pentyl-α-pyrone lactone against multidrug-resistant bacteria causing urinary tract infections (UTIs). Our study involved analyzing urine samples from humans to identify the presence of these bacteria and assess their resistance to multiple antibiotics.
The results showed that a significant portion of the samples tested positive for bacteria, with a particularly high prevalence of **E. coli**. Alarmingly, nearly all isolated strains demonstrated multidrug resistance, which poses a serious challenge for treatment. Our investigation revealed that the combination of ZnONPs and 6-pentyl-α-pyrone lactone enhanced their antibacterial effects. Particularly, we observed a substantial reduction in the minimum inhibitory concentration (MIC) for both substances when used together.
This combination therapy highlighted a promising avenue for addressing antibiotic resistance in UTIs. The study suggests that integrating ZnONPs with natural compounds could serve as a valuable strategy in combating these tough infections. However, more research is needed to fully understand the mechanisms at play and to evaluate this treatment in clinical settings.
The results showed that a significant portion of the samples tested positive for bacteria, with a particularly high prevalence of **E. coli**. Alarmingly, nearly all isolated strains demonstrated multidrug resistance, which poses a serious challenge for treatment. Our investigation revealed that the combination of ZnONPs and 6-pentyl-α-pyrone lactone enhanced their antibacterial effects. Particularly, we observed a substantial reduction in the minimum inhibitory concentration (MIC) for both substances when used together.
This combination therapy highlighted a promising avenue for addressing antibiotic resistance in UTIs. The study suggests that integrating ZnONPs with natural compounds could serve as a valuable strategy in combating these tough infections. However, more research is needed to fully understand the mechanisms at play and to evaluate this treatment in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Twitching alleviated
After experiencing my eye twitching and a racing heart, likely from Covid and stress at age 30, I decided to try magnesium for the first time. I wanted pure glycinate, but it wasn’t available, so I opted for this product due to its reasonable price. It contains various forms of magnesium, with glycinate in second place. I noticed the eye twitching stopped almost immediately. While taking other vitamins, I had to adjust my vitamin D dose, which I took separately and reduced from three to two tablets. The size of the tablets is on the larger side for me, but they have significantly improved my condition, and I’ve had no gastrointestinal problems with this brand.
Read More
3.5
Upset experienced
I have been taking this for a week and experienced an upset in my gastrointestinal tract from the first day. While it hasn't been critical, it is certainly not pleasant.
